Publications

Koch SF, Tsang SH (2018): Successes of gene therapy in late-stage and low-efficiency treatments. Accepted at Adv Exp Med Biol.

Koch SF, Duong JK, Hsu CW, Tsai YT, Lin CS, Wahl-Schott CA, Tsang SH (2017): Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa. PNAS 16;114(20):5259-5264 Highlighted at F1000

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S. (2016). Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia. Hum Mol Genet. 15;25(6):1165-75

Koch SF, Tsai YT, Duong JK, Wu WH, Hsu CW, Wu WP, Bonet-Ponce L, Lin CS, Tsang SH (2015): Halting progressive neurodegeneration in advanced retinitis pigmentosa. J Clin Invest. 125(9):3704-13 Related commentary in J Clin Invest. (Hurley JB and Chao JR: It’s never too late to save a photoreceptor) Highlighted by Science Translational Medicine (Dalkara D: Boosting the success of retinal gene therapy)

Perera A, Eisen D, Wagner M, Laube SK, Künzel AF, Koch S, Steinbacher J, Schulze E, Splith V, Mittermeier N, Müller M, Biel M, Carell T, Michalakis S (2015): TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression. Cell Rep. 11(2):283-94

Arango-Gonzalez B, Trifunović D, Sahaboglu A, Kranz K, Michalakis S, Farinelli P, Koch S, Koch F, Cottet S, Janssen-Bienhold U, Dedek K, Biel M, Zrenner E, Euler T, Ekström P, Ueffing M, Paquet-Durand F (2014): Identification of a Common Non-Apoptotic Cell Death Mechanism in Hereditary Retinal Degeneration. PLoS One. 9(11)

Michalakis S, Koch S, Sothilingam V, Garrido MG, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, Biel M (2014): Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa. Adv Exp Med Biol. 801:733-9

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA (2014): Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2. Hum Mol Genet. 23(6):1538-50

Michalakis S, Schäferhoff K, Spiwoks-Becker I, Zabouri N, Koch S, Koch F, Michael Bonin M, Biel M, Haverkamp S (2013): Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction. Cell Mol Life Sci. 70(10):1831

Brandmayr C, Wagner M, Brückl T, Globisch D, Pearson D, Kneuttinger A, Reiter V, Koch S, Hienzsch A, Thoma I, Thumbs P, Michalakis S, Müller M, Biel M, Carell T (2012): Isotope based analysis of modified tRNA nucleosides correlates modification density with translational efficiency. Angew Chem Int Ed Engl. 51(44):11162-5

Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Biel M, Mühlfriedel R, Michalakis S (2012): Gene therapy restores vision and delays degeneration in the CNGB1-/- mouse model of retinitis pigmentosa. Hum Mol Genet. 21(20):4486-96

Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Schmidt J, Zong X, Gollisch T, Biel M, Seeliger MW (2012): Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia. Adv Exp Med Biol. 723:183-9

Globisch D, Münzel M, Müller M, Michalakis S, Wagner M, Koch S, Brückl T, Biel M, Carell T (2010): Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One. 5(12):e15367

Michalakis S, Mühlfriedel R, Tanimoto N, Krishnamoorthy V, Koch S, Fischer MD, Becirovic E, Bai L, Huber G, Beck SC, Fahl E, Büning H, Paquet-Durand F, Zong X, Gollisch T, Biel M, Seeliger MW (2010): Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function. Mol Ther. 18(12):2057-63

Michalakis S, Kleppisch T, Polta SA, Wotjak CT, Koch S, Rammes G, Matt L, Becirovic E, Biel M (2010): Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice. Genes Brain Behav. 10(2):137-48