Institute of Physiology - Department of Physiological Genomics

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Major publications


Pannicke T, Wagner L, Reichenbach A, Grosche A.
Electrophysiological characterization of Müller cells from the ischemic retina of mice deficient in the leukemia inhibitory factor.
Neurosci Lett. 2018 Jan, S0304-3940(18)30053-3.


Wagner L, Pannicke T, Rupprecht V, Frommherz I, Volz C, Illes P, Hirrlinger J, Jägle H, Egger V, Haydon PG, Pfrieger FW, Grosche A.
Suppression of SNARE-dependent exocytosis in retinal glial cells and its effect on ischemia-induced neurodegeneration.
Glia. 2017 Apr, 65:1059-1071.

Schäfer N, Grosche A, Schmitt SI, Braunger BM, Pauly D.
Complement Components Showed a Time-Dependent Local Expression Pattern in Constant and Acute White Light-Induced Photoreceptor Damage.
Front Mol Neurosci. 2017 Jun, 10:197.


Grosche A, Hauser A, Lepper MF, Mayo R, von Toerne C, Merl-Pham J, Hauck SM*. 2016. The proteome of native adult Muller glial cells from murine retina.
Mol Cell Proteomics. 2016 Feb, 15:462-480.

Schäfer N, Grosche A, Reinders J, Hauck SM, Pouw RB, Kuijpers TW, Wouters D, Ehrenstein B, Enzmann V, Zipfel PF, Skerka C, Pauly D.
Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases.
Front Immunol. 2016 Nov, 7:542.

Wagner L, Pannicke T, Frommherz I, Sauer K, Chen J, Grosche A.
Effects of IP3R2 Receptor Deletion in the Ischemic Mouse Retina.
Neurochem Res. 2016 Apr, 41(4):677-86..


Preissler J, Grosche A, Lede V, Le Duc D, Krügel K, Matyash V, Szulzewsky F, Kallendrusch S, Immig K, Kettenmann H, Bechmann I, Schöneberg T, Schulz A.
Altered microglial phagocytosis in GPR34-deficient mice.
Glia. 2015 Feb;63(2):206-15.

Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT.
Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.
FASEB J. 2015 Dec, 29(12):4815-4828.


Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH.
Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland.
Exp Eye Res. 2014 Oct;127:270-9.

Pannicke T, Frommherz I, Biedermann B, Wagner L, Sauer K, Ulbricht E, Härtig W, Krügel U, Ueberham U, Arendt T, Illes P, Bringmann A, Reichenbach A, Grosche A.
Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina.
Cell Death Dis. 2014 Jul 31;5:e1353.

Wagner L, Warwick RA, Pannicke T, Reichenbach A, Grosche A, Hanani M.
Glutamate release from satellite glial cells of the murine trigeminal ganglion.
Neurosci Lett. 2014 Aug 22;578:143-7.

Lohr C, Grosche A, Reichenbach A, Hirnet D.
Purinergic neuron-glia interactions in sensory systems.
Pflugers Arch. 2014 Oct;466(10):1859-72.


Grosche A, Pannicke T, Chen J, Wiedemann P, Reichenbach A, Bringmann A.
Disruption of endogenous purinergic signaling inhibits vascular endothelial growth factor- and glutamate-induced osmotic volume regulation of Müller glial cells in knockout mice.
Ophthalmic Res. 2013;50(4):209-14.

Grosche A, Grosche J, Tackenberg M, Scheller D, Gerstner G, Gumprecht A, Pannicke T, Hirrlinger PG, Wilhelmsson U, Hüttmann K, Härtig W, Steinhäuser C, Pekny M, Reichenbach A.
Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus.
PLoS One. 2013 Jul 23;8(7):e69143.

Michalski D, Härtig W, Krügel K, Edwards RH, Böddener M, Böhme L, Pannicke T, Reichenbach A, Grosche A.
Region-specific expression of vesicular glutamate and GABA transporters under various ischaemic conditions in mouse forebrain and retina.
Neuroscience. 2013 Feb 12;231:328-44.

Vogler S, Grosche A, Pannicke T, Ulbricht E, Wiedemann P, Reichenbach A, Bringmann A.
Hypoosmotic and glutamate-induced swelling of bipolar cells in the rat retina: comparison with swelling of Müller glial cells.
J Neurochem. 2013 Aug;126(3):372-81.

Grosche A, Reichenbach A.
Neuroscience. Developmental refining of neuroglial signaling?
Science. 2013 Jan 11;339(6116):152-3.


Slezak M*, Grosche A*, Niemiec A*, Tanimoto N, Pannicke T, Münch TA, Crocker B, Isope P, Härtig W, Beck SC, Huber G, Ferracci G, Perraut M, Reber M, Miehe M, Demais V, Lévêque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Pfrieger FW.
Relevance of exocytotic glutamate release from retinal glia.
Neuron. 2012 May 10;74(3):504-16.

Grosche A, Pannicke T, Karl A, Iandiev I, Francke M, Wiedemann P, Reichenbach A, Bringmann A.
Physiologic properties of Müller cells from human eyes affected with uveal melanoma.
Invest Ophthalmol Vis Sci. 2012 Jun 28;53(7):4170-6.


Wurm A, Iandiev I, Uhlmann S, Wiedemann P, Reichenbach A, Bringmann A, Pannicke T.
Effects of ischemia-reperfusion on physiological properties of Müller glial cells in the porcine retina.
Invest Ophthalmol Vis Sci. 2011 May 18;52(6):3360-7.

Karl A, Wurm A, Pannicke T, Krügel K, Obara-Michlewska M, Wiedemann P, Reichenbach A, Albrecht J, Bringmann A.
Synergistic action of hypoosmolarity and glutamine in inducing acute swelling of retinal glial (Müller) cells.
Glia. 2011 Feb;59(2):256-66.

Agte S, Junek S, Matthias S, Ulbricht E, Erdmann I, Wurm A, Schild D, Käs JA, Reichenbach A.
Müller glial cell-provided cellular light guidance through the vital guinea-pig retina.
Biophys J. 2011 Dec 7;101(11):2611-9.

Wurm A, Pannicke T, Iandiev I, Francke M, Hollborn M, Wiedemann P, Reichenbach A, Osborne NN, Bringmann A.
Purinergic signaling involved in Müller cell function in the mammalian retina.
Prog Retin Eye Res. 2011 Sep;30(5):324-42.

Krügel K, Wurm A, Pannicke T, Hollborn M, Karl A, Wiedemann P, Reichenbach A, Kohen L, Bringmann A.
Involvement of oxidative stress and mitochondrial dysfunction in the osmotic swelling of retinal glial cells from diabetic rats.
Exp Eye Res. 2011 Jan;92(1):87-93.


Wurm A, Lipp S, Pannicke T, Linnertz R, Krügel U, Schulz A, Färber K, Zahn D, Grosse J, Wiedemann P, Chen J, Schöneberg T, Illes P, Reichenbach A, Bringmann A.
Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells.
J Neurochem. 2010 Mar;112(5):1261-72.

Pannicke T, Wurm A, Iandiev I, Hollborn M, Linnertz R, Binder DK, Kohen L, Wiedemann P, Steinhäuser C, Reichenbach A, Bringmann A.
Deletion of aquaporin-4 renders retinal glial cells more susceptible to osmotic stress.
J Neurosci Res. 2010 Oct;88(13):2877-88.


Wurm A, Erdmann I, Bringmann A, Reichenbach A, Pannicke T.
Expression and function of P2Y receptors on Müller cells of the postnatal rat retina.
Glia. 2009 Nov, 57(15):1680-90.

Wurm A, Lipp S, Pannicke T, Linnertz R, Färber K, Wiedemann P, Reichenbach A, Bringmann A.
Involvement of A(1) adenosine receptors in osmotic volume regulation of retinal glial cells in mice.
Mol Vis. 2009 Sep, 15:1858-67.


Wurm A, Pannicke T, Wiedemann P, Reichenbach A, Bringmann A.
Glial cell-derived glutamate mediates autocrine cell volume regulation in the retina: activation by VEGF.
J Neurochem. 2008 Jan, 104(2):386-99.

Wurm A, Iandiev I, Hollborn M, Wiedemann P, Reichenbach A, Zimmermann H, Bringmann A, Pannicke T.
Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina.
Exp Eye Res. 2008 Oct, 87(4):385-93.


Wurm A, Pannicke T, Iandiev I, Wiedemann P, Reichenbach A, Bringmann A.
The developmental expression of K+ channels in retinal glial cells is associated with a decrease of osmotic cell swelling.
Glia. 2006 Oct, 54(5):411-23.

Pannicke T, Iandiev I, Wurm A, Uckermann O, vom Hagen F, Reichenbach A, Wiedemann P, Hammes HP, Bringmann A.
Diabetes alters osmotic swelling characteristics and membrane conductance of glial cells in rat retina.
Diabetes. 2006 Mar, 55(3):633-9.